Office of Responsible Research Practices
The Ohio State University

IACUC News

Update on Institutional Biosafety Committee (IBC) activities during the COVID-19 pandemic

Wed, 22nd April, 2020

The IBC is supportive of research efforts involving SARS-CoV-2.  Any research that includes handling samples with the virus or research with the virus requires IBC review.  To help expedite these reviews, the IBC is meeting on an as needed basis via videoconferencing to review these new protocols and amendments.

A guidance document is available to assist with protocol preparation.  Please be sure to read this document to ensure you are providing the information required by the IBC. The IBC consists of faculty members who are also experienced researchers. Your help in preparing a well-designed research protocol is appreciated. The IBC also recommends that a new protocol be submitted rather than amending an already approved protocol if the work is not related.

Examples of Activities that require IBC review

  • Creating recombinant or synthetic nucleic acid molecules  (vector plus gene) or inserting these molecules into cell lines/tissue cultures, whole animals, humans, or plants
  • Using or creating transgenic or knock-out animals
  • Using a microorganism that is pathogenic to humans (including immunocompromised individuals), plants, or animals (based on wild-type organism)

Examples related to SAR-CoV-2:

  • Using or collecting human or non-human primate materials (body fluids, tissues, cells and established cell lines, etc.)
  • Isolation of SARS-CoV-2 virus (BSL3)
  • Propagation of SARS-CoV-2 virus (BSL3)
  • Expression of SARS-CoV-2 proteins in non virus systems (typically BSL2)
  • Expression of SARS-CoV-2 proteins in heterologous virus systems (BSL2-BSL3)
  • Vaccination studies with SARS-CoV-2 proteins (BSL2)
  • Isolation of viral nucleic acids from clinical or environmental samples (BSL2)
  • Blood serology for antibodies to SARS-CoV-2 (BSL2)
  • Nucleic acid-based intestinal microbiome studies of infected individuals (BSL2)
Category : IACUC / ORRP

IACUC Rodent Survival Surgery Policy Workshop: How to Stay Compliant

Wed, 15th April, 2020

 

The Office of Responsible Research Practices IACUC staff presents a training webinar for investigators and lab personnel on the IACUC Rodent Survival Surgery Policy.

Although this webinar is for PIs and lab personnel with IACUC approved protocols involving rodent survival surgery activities, anyone who may be considering adding a rodent survival surgery activity is welcome.

IACUC Rodent Survival Surgery Policy Workshop: How to Stay Compliant
Recorded: April 29, 2020
View the presentation video
Download the IACUC Rodent Survival Surgery Policy Training slide deck with Q & A

Contact Justin Lahmers at 614-292-0409 or lahmers.6@osu.edu with questions.

Category : IACUC / ORRP

Guidelines for animal colony maintenance during the university state of emergency

Tue, 31st March, 2020

Updated March 30, 2020

BACKGROUND

It is imperative during this time that we minimize the number of individuals coming to campus.  However, we must also ensure the safety and welfare of our research animals and maintain colonies where possible. Experimental activities should have been discontinued at this time, and access to the vivarium is limited to activities required for colony maintenance (with the exception of approved COVID-19 research activities).

ULAR staff are continuing to work and are currently on a split schedule to maximize physical distancing.

FAQS

Can I come in to the vivarium to wean and genotype my mice?
Essential colony maintenance to ensure continuity of research once this crisis passes is allowed.  Labs should have one designated essential personnel lab member, approved by the appropriate Associate or Vice Dean for Research or CCC leadership, who will be responsible for doing all the lab’s weaning/cage separation/genotyping activities on a weekly or twice weekly basis depending upon the colony size. If more than one designated staff member is needed, the number of individuals can be increased with approval from the appropriate Associate or Vice Dean for Research or CCC leadership as appropriate for the size of the colony(s). The designated lab member should plan to do the work at a time when the animal care staff will not be present in the room to promote social distancing.  If you wish to access the vivarium, please contact the ULAR team lead for your area, or the clinical veterinarian assigned to your area (see link below).  They will work with you to arrange access times that do not overlap with animal care staff and/or other investigators, to maintain appropriate social distancing.

We need you to delay all non-necessary genotyping at this time recognizing that this may need to be done depending on how long the restrictions are ongoing. If genotyping must occur, approval is needed by the respective college or the CCC as applicable. ULAR technical support can provide weaning service for your lab. Download the Request for Technical Services form.


My animals are enrolled in a long term study that started before the COVID crisis. Can I continue this study or do I need to terminate it?
Study timepoints should be altered to delay activities until the State of Emergency is lifted. If that is not feasible and/or there are concerns for animal welfare then you must speak with your college or CCC leadership, as applicable, and ULAR, for approval for an exception. If an exception is approved, you must limit the number of personnel doing animal work and conduct the work at a time when the animal care staff will not be present in the room to promote social distancing. If tissue harvesting is required, a designated laboratory staff member must be approved by the appropriate college or CCC. Please store tissues appropriately in your freezers and do not perform experiments or start primary cultures until restrictions are lifted. Work with your Associate or Vice Dean for Research to avoid overlap in personnel entering the research spaces.


Do I need to greatly reduce the number of cages I have to reduce the workload on ULAR staff?
ULAR staff are considered essential personnel, and are fully staffed to provide the animal care.  Staff are now working a split shift (morning team or afternoon team) to reduce the number of personnel present in the vivarium and support areas at any one time. At this time, ULAR does not anticipate staffing shortages that would impact their ability to provide adequate animal care. Changes in staffing may occur over time, and if services are impacted, investigators will be notified.


My IACUC protocol says I will do weekly measurement of tumors and weighing of mice. Will IACUC take action against me for not doing this during this Emergency State?
The IACUC recognizes the State of Emergency declared by the University restricts the ability of research personnel to conduct routine activities therefore the IACUC will not penalize researchers for not conducting routine monitoring during this period. ULAR technical staff can help monitor the animals condition if you anticipate that your research interventions may result in welfare issues during the State of Emergency. Download the Request for Technical Services form.


Can ULAR euthanize animals that they identify meet ERC, or have health issues for me?
Certainly.  If you have special needs for tissue collection for animals that ULAR euthanizes, please arrange with the ULAR technical staff pre-emptively so that supplies can be readily available. Download the Request for Technical Services form. If you are performing tissue harvesting for an animal that meets ERC, please follow guidelines noted above for mice in long-term studies. Euthanasia that is needed due to a welfare concern is done at no charge to the investigators. Euthanized animals will be handled at the investigator’s discretion, e.g., placed in a refrigerator for essential personnel to retrieve, frozen, discarded or placed in formalin. Retrieval can be done with approval in advance as above.


If I cannot come to campus to access the vivarium for colony maintenance, can ULAR help with this?
For any issues where a PI or team member cannot come to campus to access the vivarium, contact the ULAR team lead or the clinical veterinarian for your area. They will assist in ensuring that the necessary colony maintenance occurs. View ULAR team members and clinical veterinarians at each vivarium facility.


For all other questions:  Contact Dr. Valerie Bergdall (bergdall.1@osu.edu)

Category : IACUC / ORRP

Animal Care and Use Newsletter (Fall 2019) now available

Tue, 19th November, 2019

The Fall 2019 edition of the “Animal Care and Use Newsletter” is now available.  The new issue includes information about how to document analgesics on rodent survival surgery cards, plans to replace e-protocol system, reporting adverse events to IACUC, semiannual inspection reminders, IACUC policy updates, reminders and helpful e-Protocol tips.

Animal Care and Use Newsletter – Fall 2019

For additional information on the newsletter or any topics contained therein, please contact the IACUC office at IACUCinfo@osu.edu

Category : IACUC / ORRP

Animal Care and Use Newsletter (Spring 2019) now available

Tue, 14th May, 2019

The Spring 2019 edition of the “Animal Care and Use Newsletter” is now available on the Office of Responsible Research Practices (ORRP) IACUC Newsletters webpage. The new issue includes information about AAALAC site visit scheduled June 10-14, IACUC semiannual inspections, updates to IACUC annual review process, IACUC focused training available for personnel, zoonotic fact sheets for working with animals, IACUC policy updates; reminders about recordkeeping, investigator guidance resources, notifying ULAR when using hazardous agents, rodent surgery cage cards to be used in ULAR housing effective January 1st, tricaine-S (MS-222); also includes a helpful e-Protocol tip on how to add personnel.

Animal Care and Use Newsletter – Spring 2019

For additional information on the newsletter or any topics contained therein, please contact the IACUC office at IACUCinfo@osu.edu.

Category : IACUC / ORRP

New Online Training – Being a Principal Investigator: Roles, Responsibilities and Resources

Tue, 26th February, 2019

The Office of Research has launched a new online training to provide guidance for principal investigators and their staff. Being a Principal Investigator: Roles, Responsibilities and Resourcesis strongly recommended for principal investigators, but will benefit all members of the research community.

Course content explores the lifecycle of a sponsored project, covers research administration and compliance processes and provides access to many useful resources and tools.

To access the training:

  1. Log in to http://buckeyelearn.osu.edu
  2. Search for Being a Principal Investigator: Roles, Responsibilities and Resourcesto register
  3. Click [Request], and select course from transcript to launch the training
  4. The course takes approximately 45 minutes to complete

For more information contact Jeff Agnoli, senior staff training and development specialist for the Office of Research.

Category : IACUC / IBC / IRB / ORRP

University Laboratory Safety Committee Excellence in Safety Awards

Thu, 31st January, 2019

The University Laboratory Safety Committee’s Excellence in Safety awards recognize a university faculty or staff member, student and a laboratory research group who have made a considerable contribution to improving laboratory safety on the Ohio State campus. Such contributions can be defined as actions taken to prevent injury or illness, outstanding response and cooperation given to resolve unsafe conditions, consistent improvement during laboratory inspections, or any other consistent and proactive demonstration of efforts in support of a positive laboratory safety culture.

Environmental Health and Safety and the Office of Research coordinate the University Laboratory Safety Committee (ULSC). The ULSC works to enhance the safety culture at Ohio State by helping to shape safety programs, review and distribute new regulatory information and provide feedback from the university community regarding current laboratory safety incidents or issues.

Nominations for 2019 individual, group and student awards will be accepted through February 25, 2019.

Read more.

Category : IACUC / IBC / IRB / ORRP

Animal Care and Use Newsletter (Winter 2018) now available

Thu, 20th December, 2018

The Winter 2018 edition of the “Animal Care and Use Newsletter” is now available on the Office of Responsible Research Practices (ORRP) IACUC Newsletters webpage.  The new issue includes information about rodent surgery cage cards to be used in ULAR housing effective January 1st, AAALAC to visit Ohio State, tricaine-S (MS-222), updates to the IACUC annual review process coming soon, acknowledgment for AALAS technician certifications, zoonotic fact sheets for working with fish, employee accident reporting procedures, IACUC policy updates; reminders about personnel and training requirements, check the phone number provided in e-Protocol, use of non-pharmaceutical grade compounds; also includes a helpful e-Protocol tip on what to include in your experience and training narrative.

Animal Care and Use Newsletter – Winter 2018

For additional information on the newsletter or any topics contained therein, please contact the IACUC office at IACUCinfo@osu.edu.

Category : IACUC / ORRP

Animal Care and Use Newsletter (Spring 2018) now available

Thu, 24th May, 2018

The Spring 2018 edition of the “Animal Care and Use Newsletter” is now available on the Office of Responsible Research Practices (ORRP) IACUC Newsletters webpage.  The new issue includes information about animal hazard safety protocols, using pharmaceutical-grade saline for injection, SR buprenorphine, EHS field researcher guidelines updated, acknowledgment for AALAS technician certifications, zoonotic fact sheets for working with horses, IACUC policy updates; reminders to make sure to review approved protocol renewals, checking the correct phone number listed in e-Protocol, rodent cage-side surgery records, eIACUC new protocol activity updated on November 2 and online risk assessment tool; also includes helpful e-Protocol tips.

Animal Care and Use Newsletter – Spring 2018

For additional information on the newsletter or any topics contained therein, please contact Melinda Bruns.

Category : IACUC / ORRP

Animal Care and Use Newsletter (Fall 2017) now available

Thu, 2nd November, 2017

The Fall 2017 edition of the “Animal Care and Use Newsletter” is now available on the the Office of Responsible Research Practices (ORRP) IACUC Newsletters webpage. The new issue includes information about the update to eIACUC protocol on November 2, new online risk assessment tool, rodent cage-side surgery records, per diem rate changes, AALAS technician of the year award acknowledgment, zoonotic fact sheets for working with cattle, IACUC policy updates, reminders for reporting animal concerns and accessing CITI also includes helpful e-Protocol tips.

Animal Care and Use Newsletter – Fall 2017

For additional information on the newsletter or any topics contained therein, please contact Melinda Bruns.

Category : IACUC / ORRP