Office of Responsible Research Practices
The Ohio State University

ORRP News

Update on Institutional Biosafety Committee (IBC) activities during the COVID-19 pandemic

Posted: April 22, 2020

The IBC is supportive of research efforts involving SARS-CoV-2.  Any research that includes handling samples with the virus or research with the virus requires IBC review.  To help expedite these reviews, the IBC is meeting on an as needed basis via videoconferencing to review these new protocols and amendments.

A guidance document is available to assist with protocol preparation.  Please be sure to read this document to ensure you are providing the information required by the IBC. The IBC consists of faculty members who are also experienced researchers. Your help in preparing a well-designed research protocol is appreciated. The IBC also recommends that a new protocol be submitted rather than amending an already approved protocol if the work is not related.

Examples of Activities that require IBC review

  • Creating recombinant or synthetic nucleic acid molecules  (vector plus gene) or inserting these molecules into cell lines/tissue cultures, whole animals, humans, or plants
  • Using or creating transgenic or knock-out animals
  • Using a microorganism that is pathogenic to humans (including immunocompromised individuals), plants, or animals (based on wild-type organism)

Examples related to SAR-CoV-2:

  • Using or collecting human or non-human primate materials (body fluids, tissues, cells and established cell lines, etc.)
  • Isolation of SARS-CoV-2 virus (BSL3)
  • Propagation of SARS-CoV-2 virus (BSL3)
  • Expression of SARS-CoV-2 proteins in non virus systems (typically BSL2)
  • Expression of SARS-CoV-2 proteins in heterologous virus systems (BSL2-BSL3)
  • Vaccination studies with SARS-CoV-2 proteins (BSL2)
  • Isolation of viral nucleic acids from clinical or environmental samples (BSL2)
  • Blood serology for antibodies to SARS-CoV-2 (BSL2)
  • Nucleic acid-based intestinal microbiome studies of infected individuals (BSL2)
Category : IACUC / ORRP