External IRB Review
The Ohio State University Human Research Protection Program (HRPP) has various IRB Authorization Agreements in place for sharing IRB review between collaborating institutions, sponsors, and independent IRBs (see list below). These agreements describe each organization’s responsibilities, including those for IRB review, reporting, and research oversight. In addition, study-specific agreements with organizations can be developed, depending on the nature of the research, as described in HRPP policy, Research Performance Sites and Collaborative Off-Site Research.
Requests for Ceding Review
The Buck-IRB online system is used to make requests for review of Ohio State research by an external IRB (i.e., “ceding review” to a non-Ohio State IRB). The applicable review board is selected after basic study information is entered into the system. Selecting an external IRB will direct the user to questions and requests for document uploads (e.g., protocol, consent form) that will provide the information necessary to determine that the research meets the requirements for ceding review.
IRB Authorization Agreements
Ohio State has IRB Authorization Agreements in place with the following organizations:
- National Cancer Institute – For select NCI-sponsored clinical trials (determined by NCI)
- Nationwide Children’s Hospital – For Ohio State studies performed at NCH or involving an NCH investigator
- Ohio Clinical & Translational Science Award (CTSA) Consortium – For biomedical and cancer studies involving any of the following Ohio institutions:
- Nationwide Children’s Hospital
- University of Cincinnati
- Cincinnati Children’s Hospital Medical Center
- The MetroHealth System (Cleveland)
- The Cleveland Clinic Foundation
- University Hospitals Case Medical Center
- Case Western Reserve University
- Quorum IRB – For phase 2 studies in the Novartis Oncology Signature Program
- Western IRB – For industry-sponsored, industry-initiated clinical trials.
For questions or more information about creating study-specific agreements, contact ORRP.
SMART IRB Participating Institution
Ohio State is a participating institution in SMART IRB, a platform designed to ease common challenges and burdens associated with initiating multi-site research. SMART IRB allows institutions to minimize duplicative IRB reviews while maintaining appropriate oversight and navigate the National Institutes of Health (NIH) Policy on the Use of Single Institutional Review Board for Multi-Site Research.